Adenovirus vectors containing cell status-specific response...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S069100, C435S325000, C424S093100, C424S191100, C536S063000

Reexamination Certificate

active

06900049

ABSTRACT:
The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.

REFERENCES:
patent: 5648478 (1997-07-01), Henderson
patent: 5698443 (1997-12-01), Henderson et al.
patent: 5834306 (1998-11-01), Webster et al.
patent: 5871726 (1999-02-01), Henderson et al.
patent: 5998205 (1999-12-01), Hallenbeck et al.
patent: 2003/0095989 (2003-05-01), Irving et al.
patent: 0845537 (1998-06-01), None
patent: WO 98/39466 (1998-09-01), None
patent: WO 98/39466 (1998-09-01), None
patent: WO 95/11984 (1995-05-01), None
patent: WO 95/14100 (1995-05-01), None
patent: WO 95/14100 (1995-05-01), None
patent: WO 96/17053 (1996-06-01), None
patent: WO 96/34969 (1996-11-01), None
patent: WO 96/34969 (1996-11-01), None
patent: WO-97/01358 (1997-01-01), None
patent: WO 98/06864 (1998-02-01), None
patent: WO 98/06864 (1998-02-01), None
patent: WO 98/13508 (1998-04-01), None
patent: WO 98/35028 (1998-08-01), None
patent: WO 98/35028 (1998-08-01), None
Cuevas et al. Cancer Res 63:6877-6884, October 15, 2003.*
Hernandez-Alcoceba et al. Human Gene Therapy 13:1737-1750, Sep. 20, 2002.*
Li et aI abstract 445 from ASGT 71h Annual Meeting, Jun. 2004.*
Babiss et. al.; Cellular Promoters Incorporated into the Adenovirus Genome; 1987, J. Mol. Biol. 193: 643-650.*
Shi et. al.; Modulation of the Specificity and Activity of a Cellular Promoter in an Adenoviral Vector; 1997, Human Gene Therapy 8: 403-410.*
Bett et. al., packaging Capacity and Stability of Human adenovirus Type 5 Vectors, 1993, Journal of Virology, Vol. 67, No. 10: 5911-5921.*
Anderson; Human gene therapy, 1998, Nature Vol. 392: 25-30.*
Verma et. al.; Gene therapy-promises, problems and prospects, 1997, Nature, Vol. 389:239-242.*
Curiel; Strategies to Adapt Adenoviral Vectors forTargeted Delivery, 1999, Gene Therapy Strategies:158-171.*
Jam; Delivery of moleculat and cellular medicine to solid tumors, 1997, Journal of Controlled Release 53: 49-87.*
Hobbs; Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment, 1998, Proc. Natl. Acad. Sci. Vol. 95: 4607-4612.*
Walther; Targeted Vectors for Gene therapy of Cancer and Retrpvoral Infections, 1996, Molecular Biotechnology Vol. 6: 2670286.*
Dachs; Targeted Gene Therapy to Cancer: A Review. 1997, Oncolog Research Vol. 9: 313-325.*
Advani et. al.; Radiogenetic Therapy: On the Interaction of Viral therapy and Ionizing Radiation for improving Local Control of Tumors, 1997, Seminars in Oncology Vol. 24. No. 6: 633-638.*
Parr et. al..; Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector, 1997, Nature medicine Vol. 3, No. 3: 1145-1949.*
Orkin et al., “Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy.” pp. 1-20, Dec. 1995.*
Miller et al., “Targeted Vector for Gene Therapy.” FASEB, Vol. 9: 190-199, Feb. 1995.*
Ledley, F 0.,“Pharmaceutical Approach to Somatic Gene Therapy.” Pharmaceutical Research vol. 13: 1595-1613, Nov. 1996.*
Eck et al “Gene-Based Therapy-Chapter 5.”, Goodman & Gilman's The Pharmacological Basis of Therapeutics-Ninth Edition, McGraw-Hill: 77-101, 1996.*
Abe et al. (1993). “Characterization of Cis-Acting Elements Regulating Transcription of the Human DF3 Breast Carcinoma-Associated Antigen (N4UCI) Gene,”Proc. Natl. Sci. USA90: 282-286.
Arnberg et al. (1997). “Fiber Genes of Adenoviruses with Tropism for the Eye and the Genital Tract,”Virol.227: 239-244.
Ausubel et al. eds. (1987). Current Protocols in Molecular Bioloev Suppl. 30 Sec. 7.7.18, Table 7.7.1.
Bailey et al. (1993). “Enteric Adenovirus Type 40: Expression of EIB Proteins in Vitro and in Vivo,”Virol.193: 631-641.
Bailey et al. (1994). “Cell Type Specific Regulation of Expression from the Ad40 E1 B Promoter in Recombinant Ad5/Ad40 Viruses,”Virol.202: 695-706.
Behringeret al. (1988). “Dwarf Mice Produced by Genetic Ablation of Growth Hormone-Expressing Cells,”Genes Dev.2: 453-461.
Berkner et al. (1983). “Generation of Adenovirus by Transfection of Plasmids,”Nuc. Acid Res.11(17): 6003-6020.
Bett et al. (1993). “Packaging Capacity and Stability of Human Adenovirus Type 5 Vectors,”J. Virol.67(10): 5911-5921.
Bett et al. (1994) “An efficient and Flexible System for Construction of Adenovirus Vectors with insertions or Deletions in Early Regions 1 and 3,”Proc. Nail. A cad. Sci. USA91: 8802-8806.
Bridge et al. (1989). “Redundant Control of Adenovirus Late Gene Expression by Early Region 4,”J. Virol.63(2): 631-638.
Bunn et al. (1996). “Oxygen Sensing and Molecular Adaptation to Hypoxia,”Physiol. Rev.76(3): 839-885.
Cannio et al. (1991). “A Cell-Type Specific and Enhancer-Dependent Silencer in the Regulation of the Expression of the Human Urokinase Plasminogen Activator Gene,”Nuc. Acids Res.19(9): 2303-2308.
Coiditz. (1993). “Epidemiology of Breast Cancer,”Cancer Suppl.71(4): 1480-1489.
Dachs et al. (1996). “The Molecular Response of Mammalian Cells to Hypoxia and the Potential for Exploitation in Cancer Therapy,”Br. J. Cancer74: 5 126-5132.
Dachs et al. (1997). “Targeting Gene Expression to Hypoxic Tumor Cells,”Nat. Med.3(5): 515-520.
Feigner et al. (1989). “Cationic Liposome-Mediated Transfection,”Nature337: 387-388.
Firth et al. (1994). “Oxygen-Related Control Elements in the Phosphoglycerate Kinase 1 and Lactate Dehydrogenase A Genes: Similarities with the Erythropoietin 3′ Enhancer,”Proc. Nati. Acad. Sci. USA91: 6496-6500.
Flint. (1982). “Expression of Adenoviral Genetic Information in Productively infected Cells,”Biochem. Biophys. Acta651: 175-208.
Flint. (1986). “Regulation of Adenovirus mRNA Formation,”Adv. Vir. Res.31: 169-228.
Folkman. (1989). “What is the Evidence that Tumors are Angiogenesis Dependent?”Natl. Cancer Inst.82(1): 4-6.
Frankel et al. (1989). “Selection and Characterization of Ricin Toxin A-Chain Mutations inSaccharomyces cerevisiae,” Mol. Cell. Biol.9(2): 4 15-420.
Graham. (1984). “Covalently Closed Circles of Human Adenovirus DNA are Infectious,”EMBO J.3(12): 2917-2922.
Grand. (1987). “The Structure and Functions of the Adenovirus Early Region 1 Proteins,”Biochern. J.241: 25-38.
Grooteclaes et al. (1984). “The 6-Kilobase c-erbB2 Promoter Contains Positive and Negative Regulatory Elements Functional in Human Mammary Cell Lines,”Cancer Res.54: 4193-4199.
Guillemin et al. (1997). “The Hypoxie Response: Huffing and HIFing,”Cell89: 9-12.
Hallahan et al. (1995). “Spatial and Temporal Control of Gene Therapy Using Ionizing Radiation,”Nat. Med1(8): 786-791.
Höckel et al. (1996). “Hypoxia and Radiation Response in Human Tumors,”Semin. Rad. Oncol.˜6(1): 3-9.
Hudson Ct al. (1990). “Structure and Inducible Regulation of the Human c-crb B2Ineu Promoter,”J. Biol. Chem.265: 4389-4393.
Ido et al. (1995). “Gene Therapy for 1-lepatoma Cells Using a Retrovirus Vector Carrying Herpes Simplex Virus Thymidine Kinase Gene Under the Control of Human ci-Fetoprotein Gene Promoter,”Cancer Res.55: 3105-3109.
Ishii et al. (1987) “Characterization of the Promoter Region of the Human C-erb B-2 Protooncogene,”Proc. Nati. Acad. Sci. USA84: 4374-4378.
Jiang et al. (1997). “V-SRC Induces Expression of Hypoxia-inducible Factor 1(HIF-1) and Transcription of Genes Encoding Vascular Endothelial Growth Factor and Enolase 1: Involvement of HIF-1 in Tumor Progression,”Can. Res.57: 5328-5335.
Johnson et al

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Adenovirus vectors containing cell status-specific response... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adenovirus vectors containing cell status-specific response..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenovirus vectors containing cell status-specific response... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3436077

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.