Adenovirus vectors containing cell status-specific response...

Chemistry: molecular biology and microbiology – Vector – per se

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C435S069100, C435S325000, C424S093100, C424S191100, C536S023100

Reissue Patent

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RE042373

ABSTRACT:
The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.

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