Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1999-05-18
2000-05-02
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435325, 435369, C12N 510, C12N 15861
Patent
active
060571586
ABSTRACT:
The present invention provides improved adenovirus vectors and packaging cell lines. One type of improved adenoviral vector comprises deletions within the E2b region of the adenoviral genome. These E2b-deleted virus are used in conjunction with novel cell lines that constitutively express E2b gene products. The present invention further provides adenoviral vectors deleted for all viral coding regions. These "gutted" vectors permit the transfer of large genes to cells as demonstrated herein by the transfer of the dystrophin gene to the muscle of mice. The E2b-deleted vectors and the gutted vectors provide improved adenoviral vectors useful for a wide variety of gene therapy applications.
REFERENCES:
patent: 5919676 (1999-07-01), Graham et al.
Chamberlain Jeffrey S.
Hartigan-O'Connor Dennis J.
Regents of the University of Michigan
Schwartzman Robert A.
LandOfFree
Adenovirus vectors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adenovirus vectors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenovirus vectors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1593107