Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2007-11-20
2007-11-20
Sullivan, Daniel M (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S320100, C435S091100, C435S091400, C435S183000, C424S093100, C530S412000, C536S023400, C514S04400A
Reexamination Certificate
active
09245603
ABSTRACT:
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene such that novel tropism is achieved. This recombinant adenovirus has a fiber gene modified in the HI loop domain.
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Curiel David T.
Dmitriev Igor
Krasnykh Victor N.
Frommer & Lawrence & Haug LLP
Kowalski Thomas J.
Lu Deborah L.
Makar Kimberly A.
Sullivan Daniel M
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