Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-07-26
2005-07-26
Winkler, Ulrike (Department: 1648)
Chemistry: molecular biology and microbiology
Vector, per se
C424S093100, C424S093200, C424S185100, C424S186100, C424S199100, C424S233100, C435S069100, C435S455000, C435S456000, C536S023720
Reexamination Certificate
active
06921663
ABSTRACT:
The present invention provides a method for constructing a fiber-mutant adenovirus vector in which a foreign peptide is introduced by a simple system into the fiber HI loop-coding gene of adenovirus; and provides a fiber-mutant adenovirus vector which is constructed by this method.
REFERENCES:
patent: 6210946 (2001-04-01), Curiel et al.
patent: WO 99/39734 (1999-08-01), None
patent: WO 00/12738 (2000-03-01), None
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Arap et al. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science (1998) vol. 279, pp. 377-380.
Liqiong LIU et al., “Incorporation of Tumor Vasculature Targeting Motifs into Moloney Murine Leukemia Virus Env Escort Proteins Enhances Retrovirus Binding and Transduction of Human Endothelial Cells”, Journal of Virology, vol. 74, No. 11, Jun. 2000, pp. 5320-5328.
Hayakawa Takao
Mizuguchi Hiroyuki
Foley & Lardner LLP
National Institute of Health Sciences
Winkler Ulrike
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