Adenovirus helper-free recombinant AAV Virion production

Details Adenovirus helper-free recombinant AAV Virion production Adenovirus helper-free recombinant AAV Virion production

1996-11-07

1999-12-21

Ketter, James

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

435369, 536 231, C12N 700

Patent

active

060047976

ABSTRACT:
Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producing rAAV virions are also provided. The methods can be practiced to produce commercially significant levels of rAAV particles without also generating significant levels of infectious helper virus or other contaminating by-products.

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