Adenovirus 36 E4 orf 1 gene and protein and their uses

Details Adenovirus 36 E4 orf 1 gene and protein and their uses Adenovirus 36 E4 orf 1 gene and protein and their uses

2011-08-30

2011-08-30

Li, Bao (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S303000, C424S223100, C424S093100, C514S04400A

Reexamination Certificate

active

08008436

ABSTRACT:
Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.

REFERENCES:
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