Adenoviral vectors for treatment of hemophilia

Details Adenoviral vectors for treatment of hemophilia Adenoviral vectors for treatment of hemophilia

1995-06-07

1999-08-10

Ketter, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, 435367, 435370, A01N 4304

Patent

active

059359358

ABSTRACT:
An adenoviral vector including at least one DNA sequence encoding a clotting factor, such as, for example, Factor VIII, or Factor IX. Such vectors may be administered to a host in an amount effective to treat hemophilia in the host. The vectors infect hepatocytes very efficiently, whereby the hepatocytes express the DNA sequence encoding the clotting factor.

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