Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2002-11-27
2010-11-09
Sajjadi, Fereydoun G (Department: 1633)
Chemistry: molecular biology and microbiology
Vector, per se
C435S235100, C514S04400A
Reexamination Certificate
active
07829329
ABSTRACT:
Adenoviral vectors, including mutant adenoviruses, that have restriction sites in the E3 region, that facilitate its partial or total deletion, or select genes contained therein, and optionally compositions and methods for substituting heterologous gene(s) in the partially or totally deleted E3 region(s), which heterologous gene(s) being operably linked to endogenous adenoviral transcriptional control sequences will exhibit an expression pattern, both in terms of timing and degree of expression, similar to the endogenous adenoviral gene(s) that it replaces, and further optionally including mutations in other parts of the adenoviral genome, including certain E1B or E1A regions, and that have applications for diagnosing or treating disease, preferably disease involving unwanted cell growth, including cancer.
REFERENCES:
patent: 6100086 (2000-08-01), Kaplan et al.
Bett et al. PNAS 91:8802-8806, 1994.
Virology Jan. 15, 1985;140(1):28-43; “DNA sequence of the early E3 transcription unit of adenovirus 5,” Cladaras C, Wold WS.
Mol Ther. Apr. 2003;7(4):435-7, “A multitasking oncolytic adenovirus vector,” Toth K, Doronin K, Tollefson AE, Wold WS.
J Virol. Oct. 1992;66(10):5914-23, “Map of cis-acting sequences that determine alternative pre-mRNA processing in the E3 complex transcription unit of adenovirus,” Brady HA, Scaria A, Wold WS.
Virology. Dec. 1994;205(2):406-16, “Fine-mapping of sequences that suppress splicing in the E3 complex transcription unit of adenovirus,” Scaria A, Wold WS.
Hawkins Lynda K.
Hermiston Terry
Johnson Leisa
Fabian Gary R.
Giotta Gregory J.
Onyx Pharmaceuticals Inc.
Sajjadi Fereydoun G
LandOfFree
Adenoviral vectors for treating disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adenoviral vectors for treating disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenoviral vectors for treating disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4242192