Adenoviral vectors for gene therapy containing deletions in the

Details Adenoviral vectors for gene therapy containing deletions in the Adenoviral vectors for gene therapy containing deletions in the

1997-07-16

1999-03-16

Crouch, Deborah

Chemistry: molecular biology and microbiology

Vector, per se

435456, 435457, C12N 1500, C12N 1586

Patent

active

058828770

ABSTRACT:
Adenoviral vectors which contain deletions of the early regions and/or late genes provide efficient delivery and expression of foreign nucleic acids of interest to patients. These vectors have a particular use in the treatment of cystic fibrosis patients. Furthermore, PAV vectors provide for a second generation of adenoviral vectors that contain the 5' ITR's, the packaging signal and the E1A enhancer. Other adenoviral vectors contain a deletion of the E1 region or a deletion of E4 but retain orf3 or orf6, and can either retain or delete the E3 region.

REFERENCES:
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