Adenoviral vectors and uses thereof

Details Adenoviral vectors and uses thereof Adenoviral vectors and uses thereof

2005-10-12

2010-06-22

Peng, Bo (Department: 1648)

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

C424S233100

Reexamination Certificate

active

07741099

ABSTRACT:
The present invention relates to recombinant adenoviral vectors based on adenoviruses that encounter pre-existing immunity in a minority of the human population and which harbor a chimeric capsid. The chimeric capsid comprises fiber proteins that have at least the knob domain of a human adenovirus that binds to the Coxsackievirus and Adenovirus Receptor (CAR) and a hexon protein from an adenovirus serotype that encounters pre-existing immunity in a low percentage of the human population.

REFERENCES:
patent: WO 98/32842 (1998-07-01), None
patent: WO 98/40509 (1998-09-01), None
patent: WO 00/03029 (2000-01-01), None
patent: WO 00/12738 (2000-03-01), None
patent: WO 00/70071 (2000-11-01), None
patent: WO 03/062400 (2003-07-01), None
patent: WO 2004/037294 (2004-05-01), None
PCT International Preliminary Report on Patentability, PCT/EP2005/055183, dated Jan. 26, 2007.
U.S. Appl. No. 11/667,975, filed May 16, 2007, Havenga et al., Multivalent Vaccines Comprising recombinant Viral Vectors.
U.S. Appl. No. 11/786,409, filed Apr. 11, 2007, Vogels et al., Complementing Cell Lines.
U.S. Appl. No. 11/809,697, filed Jun. 1, 2007, Hateboer et al., Recombinant Protein Production in a Human Cell.
U.S. Appl. No. 11/899,572, filed Sep. 5, 2007, Vogels et al., Stable Adenoviral Vectors and Methods for Propagation Thereof.
U.S. Appl. No. 11/978,043, filed Oct. 25, 2007, Vogels et al., New Settings for Recombinant Adenoviral-Based Vaccines.
U.S. Appl. No. 11/980,222, filed Oct. 29, 2007, Bout et al., Serotypes of Adenovirus and Uses Thereof.
U.S. Appl. No. 12/225,259, filed Sep. 16, 2008, Barouch et al., Recombinant Adenoviruses Based on Seroytype 26 and 48, and Use Thereof.
U.S. Appl. No. 12/225,673, filed Sep. 26, 2008, Havenga et al., Compositions Comprising a Recombinant Adenovirus and an Adjuvant.
Barouch et al., Immunogenicity of Recombinant Adenovirus Serotype 35 Vaccine in the Presence of Pre-Existing Anti-Ad5 Immunity, Journal of Immunology, May 15, 2004, pp. 6290-6297, vol. 172, No. 10.
Crawford-Miksza et al., Analysis of 15 Adenovirus Hexon Proteins Reveals the Location and Structure of Seven Hypervariable Regions Containing Serotype-Specific Residues, Journal of Virology, Mar. 3, 1996, pp. 1836-1844, vol. 70, No. 3, The American Society of Microbiology, United States.
Gall et al., Construction and Characterization of Hexon-Chimeric Adenoviruses: Specification of Adenovirus Serotype, Journal of Virology, Dec. 1998, pp. 10260-10264, vol. 72, No. 12.
Ganesh et al., Adenovirus 35 Vectors with Fiber Chimeras Exhibit Altered Tropism In Vivo, Molecular Therapy, May 2003, pp. S53 vol. 7, No. 5, San Diego, USA.
Roberts et al., Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity, Nature, May 11, 2006, pp. 239-243, vol. 441, No. 7090.
Roy et al., Circumvention of Immunity to the Adenovirus Major Coat Protein Hexon, Journal of Virology, Aug. 1998, pp. 6875-6879, vol. 72, No. 8, The American Society for Microbiology, United States.
Rux et al., Type-Specific Epitope Locations Revealed by X-Ray Crystallographic Study of Adenovirus Type 5 Hexon, Molecular Therapy: The Journal of the American Society of Gene Therapy, Jan. 2000, pp. 18-30, vol. 1, No. 1.
Rux et al., Structural and Phylogenetic Analysis of Adenovirus Hexons by Use of High-Resolution X-Ray Crystallographic, Molecular, Modeling, and Sequence-Based Methods, Journal of Virology, Sep. 2003, pp. 9553-9566, vol. 77, No. 17.
Sakurai et al., Efficient Gene Transfer into Human CD34+ Cells by an Adenovirus Type 35 Vector, Gene Therapy, Jun. 2003, pp. 1041-1048, vol. 10, No. 12.
Seshidhar et al., Development of Adenovirus Serotype 35 as a Gene Transfer Vector, Virology, Jul. 5, 2003, pp. 384-393, vol. 311, No. 2, Academic Press, Orlando, US.
Shayakhmetov et al., The Interaction between the Fiber Knob Domain and the Cellular Attachment Receptor Determines the Intracellular Trafficking Route of Adenoviruses, Journal of Virology, Mar. 2003, pp. 3712-3723, vol. 77, No. 6.
Sumida et al., Neutralizing Antibodies to Adenovirus Serotype 5 Vaccine Vectors Are Directed Primarily against the Adenovirus Hexon Protein, Journal of Immunology, Jun. 2005, pp. 7179-7185, vol. 174, No. 11.
Vigne et al., RCD Inclusion in the Hexon Monomer Provides Adenovirus Type 5-Based Vectors with a Fiber Knob-Independent Pathway for Infection, Journal of Virology, Jun. 1999, pp. 5156-5161, vol. 73, No. 6, The American Society for Microbiology, US.
Vogels et al, Replication-Deficient Human Adenovirus Type 35 Vectors for Gene Transfer and Vaccination: Efficient Human Cell Infection and Bypass of Preexisting Adenovirus Immunity, Journal of Virology, Aug. 2003, pp. 8263-8271, vol. 70, No. 15, The American Society for Microbiology, US.
Youil et al., Hexon Gene Switch Strategy for the Generation of Chimeric Recombinant Adenovirus, Human Gene Therapy, Jan. 20, 2002, pp. 311-320, vol. 13, No. 2.
International Preliminary Report on Patentability, PCT/EP2005/055183, dated Jan. 26, 2007.
International Search Report, PCT/EP2005/055183, dated Jul. 10, 2006.
U.S. Appl. No. 12/445,086, filed May 28, 2009, Vogels et al., Gene Delivery Vectors Provided With a Tissue Tropism for Smooth Muscle Cells, and/or Endothelial Cells.
U.S. Appl. No. 12/460,678, filed Jul. 23, 2009, Vogels et al., Serotype of Adenovirus and Uses Thereof.
U.S. Appl. No. 12/583,628, filed Aug. 24, 2009, Havenga et al., New Settings for Recombinant Adenoviral-Based Vaccines.

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