Adenoviral vector system

Details Adenoviral vector system Adenoviral vector system

1995-01-17

1999-03-09

Ketter, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 9321, 435325, 435369, 435353, 4353201, 4352351, A61K 3500

Patent

active

058801022

ABSTRACT:
The present invention relates, in general, to a gene transfer system and, in particular, to an adenoviral vector system suitable for use in gene transfer and gene therapy.

REFERENCES:
patent: 5428070 (1995-06-01), Cooke et al.
Bett et al., An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3, Proc. Nat. Acad. Sci. USA 91:8802-8806, 1994.
Hearing and Shenk, The adenovirus type 5 E 1 a transcriptional control region contains a duplicated enhancer element, Cell 33:695-702, 1983.
Massie et al., Construction of a helper-free recombinant adenovirus that expresses polyomavirus large T antigen, Mol. Cell. Biol. 6:2872-2883, 1986.
Zabner et al., Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: Efficiency of adenovirus-mediated gene transfer in vitro, Human Gene Therapy 5:585-593, 1994.
Gerard and Meidell, Adenovirus-mediated gene transfer, Trends Cardiovasc. Med. 3: 171-177, 1993.
Friedman et al., Cellular promoters incorporated into the adenovirus genome; Mol. Cell. Biol. 6: 3791-3797, 1986.

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