Adenoviral-mediated gene transfer to synovial cells in vivo

Details Adenoviral-mediated gene transfer to synovial cells in vivo Adenoviral-mediated gene transfer to synovial cells in vivo

1995-04-14

1998-05-05

Stanton, Brian R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435 695, 4351723, 4353201, 514 44, A61K 4800, C12N 1509, C12N 1563

Patent

active

057470723

ABSTRACT:
This invention provides recombinant adenoviral vectors having an expression control sequence operatively linked to a gene that encodes an anti-inflammatory polypeptide or that produces on transcription an anti-inflammatory ribozyme or antisense RNA molecule. This invention also provides methods of transferring a gene to a synovial cell by transducing the synovial cell in vivo, with a recombinant adenoviral vector. This invention also provides methods of treating an inflammatory condition in the joint of a subject comprising administering to the joint a therapeutically effective amount of a recombinant adenoviral vector having an expression control sequence operatively linked to a gene that encodes an anti-inflammatory polypeptide or that produces on transcription an anti-inflammatory ribozyme or antisense RNA molecule.

REFERENCES:
Davidson, Beverly L. et al., "A model system for in vivo gene transfer into the central nervous system using an adenoviral vector." Nature Genetics. 3:219-223 (1993).
Dinarello, C.A., "Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonism." Int. J. Tiss. Reac. XIV (2)65-75 (1992).
Jaffe, H.A. et al., "Adenovirus-mediated in vivo gene transfer and expression in normal rat liver." Nature Genetics. 1:372-378 (1992).
Harris, Edward D., "Excitement in synovium: The rapid evolution of understanding of rheumatoid arthritis and expectations for therapy." J. Rheumatol. Suppl. 32:3-5 (1992).
Remmers, Elaine F. et al. "Cytokines and growth regulation of synoviocytes from patients with rheumatoid arthritis and rats with streptococcal cell wall arthritis." Growth Factors. 2:179-188 (1990).
Graham and Van Der Eb, "A new technique for the assay of infectivity of human adenovirus 5 DNA." Virology. 52:456-467 (1973).
Bodon and Prohaszka, "Isolation of an adenovirus from rabbits with diarrhea." Acta. Vet. Hung. 28:247-255 (1980).
Muro-Cacho, Carlos A. et al., "Gene transfer in human lymphocytes using a vector based on adeno-associated virus." J. of Immunotherapy. 11:231-237 (1992).
Cassel, Aliza et al., "Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells." Experimental Hematology. 21:585-591 (1993).
Roessler and Davidson, "Genetic modification of synoviocytes in vivo using recombinant adenoviral vectors." Clinical Research 41(2) :171A(1993).
Arend, William P. et al., "Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist." J. Clin. Invest. 85:1694-1697 (1990).
Koch, Alisa E. et al., "Expression of interleukin-1 and interleukin-1 receptor antagonist by human rheumatoid synovial tissue macrophages." Clin. Immun. and Immunopathology. 65:23-29 (1992).
Yocum, David E. et al., "Hyperplastic synoviocytes from rats with streptococcal cell wall-induced arthritis exhibit a transformed phenotype that is thymic-dependent and retinoid inhibitable." Am. J. of Pathology. 132:38-48 (1988).
Quantin, B. et al., "Adenovirus as an expression vector in muscle cell in vivo." Proc. Natl. Acad. Sci. 89:2581-2584 (1992).
Hurwitz and Chinnadurai, "Evidence that a second tumor antigen coded by adenovirus early gene region Ela is required for efficient cell transformation." Proc. Natl. Acad. Sci. 82:163-167 (1985).
Haskill, Stephen et al., "cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium." Proc. Natl. Acad. 88:3681-3685 (1991).
Bodon, L. et al., "Isolation of an adenovirus from rabbits." Preliminary Report, Veterinary Research Institute. 73-75 (1979).
Bandara et al. 1992 DNA and Eeu Biology 11(3):227-331.
Rosenfeld et al. 1992. Cell 68:143-155.
Berkner. 1989 6:616-629.
Uhlmann et al. 1990 Chemical Reviews 90(4): 544-579.
Carter et al. 1990. nature 344:633-638.
Hannum et al 1990. Nature 343 : 336-340.
Eisenberg et al. 1990. Nature 343: 341-346.

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