Adenoviral-mediated gene transfer to adipocytes

Details Adenoviral-mediated gene transfer to adipocytes Adenoviral-mediated gene transfer to adipocytes

1996-06-26

1999-02-09

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 937, 424 9321, 435325, 4353201, 4351723, 514 44, A61K 3512, A61K 4800, C12N 1509, C12N 1586

Patent

active

058690379

ABSTRACT:
The present invention provides for in vivo gene transfer to adipocytes mediated by adenovirus and, in particular, the in vivo transfer of toxic genes as a means of reducing adiposity, as well as the transfer of genes encoding angiogenic substances to induce new blood vessel growth. The present invention also provides for the in vivo gene transfer to adipocytes to supply a source of proteins to be used in the local milieu of the adipocyte tissue or to be secreted and used systemically. Further, the present invention provides for the transfer of the adipocytes to other sites within a host, following adenoviral-mediated transfer of genes to the adipocytes in vivo, to allow for the exploitation of the modified adipocytes as a transferable means for the production of protein.

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