Adenosine receptor antagonists and methods of making and...

Details Adenosine receptor antagonists and methods of making and... Adenosine receptor antagonists and methods of making and...

2006-07-10

2009-08-25

Berch, Mark L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S081000, C514S263220, C514S263240, C514S263350, C514S263360

Reexamination Certificate

active

07579354

ABSTRACT:
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A1receptor. Adenosine A1antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable.In one embodiment, the invention features a compound of formula I:

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