Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-12-21
2008-12-16
Jiang, Dong (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C514S002600, C424S185100
Reexamination Certificate
active
07465789
ABSTRACT:
The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by adenosine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian adenosine receptor.
REFERENCES:
patent: 5871963 (1999-02-01), Conley et al.
patent: 7157244 (2007-01-01), Hedrick et al.
patent: WO 97/20045 (1997-06-01), None
patent: WO 00/22131 (2000-04-01), None
Sequence search results: sequence alignment between SEQ ID NO:2 of the present application and SEQ ID NO:2 of US5,871,963. Accessed Apr. 30, 2008.
Kaiser, Sonya M. and Quinn, Ronald J., Adenosine receptors as potential therapeutic targets.Drug Discovery Today4(12), 542-551 (Dec. 1999).
Muller, C.E., Adenosine Receptor Ligands-Recent Developments Part I. Agonists.Current Medicinal Chemistry7:1269-1288 (Dec. 2000).
Poulsen, Sally-Ann and Quinn, Ronald J., Adenosine Receptors: New Opportunities for Future Drugs.Bioorganic&Medicinal Chemistry6:619-641 (Jun. 1998).
Gustafson Eric L.
Hedrick Joseph A.
Lachowicz Jean E.
Wang Wei
Fuentes Gloria M.
Jiang Dong
Schering Corporation
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