Adenosine receptor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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Details

C435S325000, C435S252300, C435S348000, C435S349000, C435S361000, C435S365000, C435S353000, C435S367000, C435S252330, C435S253300, C435S252500, C435S320100, C536S023500, C530S350000

Reexamination Certificate

active

09765034

ABSTRACT:
The present invention provides an isolated mammalian adenosine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by adenosine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian adenosine receptor.

REFERENCES:
patent: 5871963 (1999-02-01), Conley et al.
patent: WO 97/20045 (1997-06-01), None
patent: WO 00/22131 (2000-04-01), None
Kaiser, Sonya M. and Quinn, Ronald J., Adenosine receptors as potential therapeutic targets.Drug Discovery Today4(12), 542-551 (1999).
Muller, C.E., Adenosine Receptor Ligands-Recent Developments Part I. Agonists.Current Medicinal Chemistry7:1269-1288 (2000).
Poulsen, Sally-Ann and Quinn, Ronald J., Adenosine Receptors: New Opportunities for Future Drugs.Bioorganic&Medicinal Chemistry6:619-641 (1998).

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