Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles,

Details Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles,

1994-03-04

1995-01-17

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544369, A61K 31495, C07D41306, C07D41706

Patent

active

053825845

ABSTRACT:
A series of 1-piperazinyl-N-phenylacetamide derivatives of 4,5-diphenyl-oxazoles, thiazoles, and imidazoles which are novel adenosine transport inhibitors have been found to provide effective antiischemic protection for CNS and cardiac tissue, particularly neurons. A method of treatment to protect against CNS ischemia, such as that resulting from trauma, stroke, or other ischemic conditions, comprises administration of these novel compounds to an individual in need of such treatment.

REFERENCES:
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patent: 4020082 (1977-04-01), Marchetti
patent: 4101660 (1978-07-01), Inoue et al.
patent: 4766125 (1988-08-01), Van Daele
patent: 4948796 (1990-08-01), Hiraiwa et al.
Inoue et al, "2-Aminomethyl-5-phenyloxazoles", Chemical Abstracts, vol. 91 (1979), pp. 707, paragraph: 91:56986x.
Inoue et al, "2-Aminomethyl-5-phenyloxazoles", Chemical Abstracts, vol. 91 (1979), pp. 707-708, paragraph: 91:56987y.

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