Adenosine pyrophosphate polynucleotide compound

Details Adenosine pyrophosphate polynucleotide compound Adenosine pyrophosphate polynucleotide compound

1982-02-01

1984-09-18

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, 435 91, C07H 1910, C07H 1920, C12P 1934

Patent

active

044725728

ABSTRACT:
Composition and methods of production of the compound P.sup.1 -adenosine, P.sup.2 -(3' nucleotide monophosphate)-5' pyrophosphate (AppNp) are disclosed. AppNp is useful in the synthesis of a predetermined sequence of RNA using the enzyme T4 RNA ligase. The use of this invention in the field of recombinant DNA will greatly enhance the ability to synthesize genes of known composition.

REFERENCES:
patent: 4328336 (1982-05-01), Robins et al.
Smith et al., Cyclic Phosphate. IV. Ribonucleaside-3',5' Cyclic Phosphates, A General Method of Synthesis and some Properties, The Journal of American Chemical Society, 8,3 pp. 698-706 (1961).

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