Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1998-05-19
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514456, 514617, 546141, 549399, 564166, A61K 3135, A61K 3147
Patent
active
057536740
ABSTRACT:
The subject invention provides for novel compounds for inactivating viruses. These compounds include 6-nitroso-1,2-benzopyrone, 3-nitrosobenzamide, 5-nitroso-1 (2H)-isoquinolinone, 7-nitroso-1(2H)-isoquinolinone, 8-nitroso-1 (2H)-isoquinolinone. The invention also provides for compositions containing one or more of the compounds, and for methods of treating viral infections, cancer, infectious virus concentration with the subject compounds and compositions.
REFERENCES:
patent: 5519053 (1996-05-01), Kun
1923, J. Pharm. Soc. Jap. 498:615.
Aldovini et al., 1990, "Mutations of RNA and protein sequences involved in human immunodeficiency virus Type I packaging result in production of noninfectious virus," J. Virol. 64:1920-1926.
Borek et al., 1984, "Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis," Proc. Natl. Acad. Sci. U.S.A. 81:243-247.
Buki et al., 1991, "Destabilization of Zn.sup.2+ coordination in ADP-ribose transferase (polymerizing) by 6-nitroso-1,2-benzopyrone coincidental with inactivation of the polymerase but not the DNA binding function," FEBS Lett. 290:181-185.
Buki et al., 1991, "Inhibitor Binding of Adenosine Disphosphoribosyl Transferase to the DNA Primer Site of Reverse Transcriptase Templates," Biochem. Biophys. Res. Commun. 180:496-503.
Buki et al., 1991, "Destabilization of Zn(II) coordination in poly (ADP-ribose) polymerase by 6-nitroso-1,2-benzopyrone coincidental with inactivation of the polymerase but not the DNA binding function," The Paul Mandel International Meeting of Poly (ADP-Ribosyl)ation Reactions, Abstract 22C May 30, 1991.
Casasfinet et al., 1993, "3-nitrosozenzamide (NOBA) reacts with the zinc-finger sequence of HIV-1 nucleocapsid protein (P7) and phage T4 gene 32 protein (GP32)," Biophys. Journal 64(2):A125.
Chuang et al., 1993, "Inhibition of the Replication of Native and 3'-azido-2',3'-dideoxy-thymidine (AZT)-resistant simian immunodeficiency virus (SIV) by 3-nitrosobenzamide," FEBS Lett. 326:140-144.
Cole et al., 1991, "Inhibition of HIV-1 IIIb Replication in AA-2 and MT-2 Cells in Culture By Two Ligands of Poly (ADP-RIBOSE) Polymerase: 6-Amino-1,2-Benzopyrone and 5-Iodo-6-Amino-1,2-Benzopyrone," Biochem. Biophys. Res. Commun. 180:504-514.
Elhardt et al., 1988, "Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs," J. Med. Chem. 31:323-329.
Farzaneh et al., 1988, ADP-ribosylation is involved in the integration of foreign DNA into Nucleic Acids Res. 16:11319-11326.
Furlini et al., 1991, "Increased poly (ADP-ribose) polymerase activity in cells infected by human immunodeficiency virus type-1," Microbiologica 14(2):141-148.
Gorelick et al., 1988, "Point mutants and Moloney murine leukemia virus that fail to package viral RNA: Evidence for specific RNA recognition by a zinc finger-like protein sequence," Proc. Natl. Acad. Sci. USA 85:8420-8424.
Gorelick et al., 1990, "Noninfectious Human Immunodeficiency Virus Type 1 Mutants Deficient in Genomic RNA". J. Virol. 64:3207-3211.
Gradwohl et al., 1990, "The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA," Proc. Natl. Acad. Sci. USA 87:2990-2994.
Grosso & Pitot, 1984, "Modulation of C-MYC Expression in the HL-60 Cell Line," Biochemistry 119:473-480.
Hakam et al., 1987, "Catalytic Activities of Synthetic Octadeoxyribonucleotides as Coenzymes of Poly (ADP-ribose) Polymerase and the Identification of New Enzyme Inhibitory Site," FEBS Lett. 212:73-78.
Henderson et al., 1981, "Primary Structure of Low Molecular Weight Nucleic Acid-binding Proteins of Murine Leukemia Viruses," Biol. Chem. 256:8400-8406.
Ibne-Rasa et al., 1963, "o-Nitrosobenzamide. A Possible Intermediate in the von Richter Reaction," J. Org. Chem. 28:3240-3241.
Ikushima, T., 1990, "Bimodal induction of sister-chromatid exchanges by luminol, an inhibitor of poly(ADP-ribose) synthetase, during the S-phase of the cell cycle," Chromosoma 99:360-364.
Ito et al., 1953, "Coumarin Derivatives for Medicinal Purposes," J. Pharm. Soc. Jap. 73:351-355.
Kirsten et al., 1991, "Cellular Regulation of ADP-Ribosylation of Proteins IV. Conversion of Poly (ADP-Ribose) Polymerase Activity to NAD-glycohydrolase During Retinoic Acid-Induced Differentiation of HL60 Cells," Experimental Cell Research 194:1-8.
Kitagawa et al., 1958, "Coumarin Derivatives for Medicinal Purposes," Chem. Abstr. 52:18874c.
Kitigawa, Haruo, 1954, "Coumarin Derivatives for Medicinal Purposes," J. Pharm. Soc. Jap. 74:271-278.
Kitigawa & Iwaki, 1963, "Coumarin Derivatives for Medicinal Purposes," Yakugaku Zasshi 83:1124-1128.
Kokotos et al., 1986, "Synthesis and Study of Substituted Coumarins. A Facile Preparation of D.L-o-Tyrosine," J. Heterocyclic Chem. 23:87-92.
Kovacic et al., 1990, "Reduction potentials in relation to physiological activities of benenzoid and heterocyclic nitroso compounds: comparison with the nitro precursors," Bioorganic Chemistry 18:265-275.
Krasil'Nikov et al., 1991, "Inhibitors of ADP-ribosylation as antiviral drugs: Experimental study of the model of HIV infection," Vopr. Virusol. (Russia) 36(3):216-218.
KrasilNikov et al., 1991, Chemical Abstracts 115:222844k.
Kun et al., 1983, "Cell cycle-dependent intervention by benzamide of carcinogen-induced neoplastic transformation and in vitro poly(ADP-ribosyl)ation of nuclear proteins in human fibroblasts," Proc. Natl. Acad. Sci. U.S.A. 80:7219-7223.
Lever et al., 1989, "Identification of a Sequence Required for Efficient Packaging of Human Immunodeficiency Virus Type 1 RNA into Virons," J. Virol. 63:4085-4087.
McClelland et al., 1987, "Products of the reductions of 2-nitroimidzoles," J. Am. Chem. Soc. 109:4308-4314.
Merchant et al., 1983, "Synthesis of Some Benzopyranocyclopentapyridine and Pyranoacridine Derivatives," Chem. Abstr. 99:105153z.
Meric and Goff, 1989, "Characterization of Moloney Murine Leukemia Virus Mutants with Single-Amino-Acid Substitutions in the Cys-His Box of the Nucleocapsid," J. Virol. 63:1558-1568.
Milo et al., 1985, "Inhibition of carcinogen-induced cellular transformation of human fibroblasts by drugs that interact with the poly(ADO-ribose) polymerase system," FEBS Lett. 179:332-336.
Mulcahy et al., 1989, "Cytotoxicity and glutathione depletion by I-methyl-2-nitrosoimidazole in human colon cancer cells," Biochem. Pharm. 38:1667-1671.
Nakayashu et al., 1988, "Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of poly(ADP-ribose) polymerase," Proc. Natl. Acad. Sci. U.S.A. 85:9066-9070.
Noss et al., 1988, "Preparation, toxicity and mutagenicity of 1-methyl-2-nitrosoimidazole," Biochem. Pharm. 37:2585-2593.
Noss et al., 1989, "I-Methyl-2-nitrosoimidazole: cytotoxic and glutathione depleting capabilities," Int. J. Radiation Oncology Biol. Phys. 16:1015-1019.
Pearson et al., 1991, Chemical Abstracts 114 Col. 23803a.
Rao, et al., 1989, "Mercaptocoumarinoxazoles," Chem. Abstr. 111:232636a.
Rice et al., 1992, "Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly (ADP-ribose) polymerase," Proc. Natl. Sci. USA 89:7703-7707.
Rice et al., 1993, "Novel Zinc-Ejecting C-Nitroso Compounds Inhibit the Infectious and Expressive Phases of HIV-1 Life Cycle," Journal of Cellular Biochemistry S17E:22.
Rice et al., 1993, "Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds," Nature 361:473-475.
Rice et al., 1993, "The site of antiviral action of 3-nitrosobenzamide on the infectivity process of HIV in human lymphocytes," Proc. Natl. Sci. U.S.A. 90(20):9721-9724.
Romano et al., "Inhibitors of ADP-ribosyl transferase suppress the mitogeni actions exerted by tumour promoters, but not those evoked by peptide mitogens, in primary neonatal rat hepatocytes," Carcinogenesis 9:2147-2154.
Seidel et al., 1975, "Oxidation of Aromatic Hydrazides," Chemical Abstracts 82 Col. 16505X.
Shell et al., 1991, Chemical Abstracts 116: 193929e.
Shima et al., 1989, "Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide," Proc.
Kun Ernest
Mendeleyev Jerome
Rice William C.
Halluin Albert P.
Ivy C. Warren
Mach D. Margaret
Octamer, Inc.
LandOfFree
Adenosine diphosphoribose polymerase binding nitroso aromatic co does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adenosine diphosphoribose polymerase binding nitroso aromatic co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenosine diphosphoribose polymerase binding nitroso aromatic co will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1853340