Adenosine diphosphoribose polymerase binding nitroso aromatic co

Details Adenosine diphosphoribose polymerase binding nitroso aromatic co Adenosine diphosphoribose polymerase binding nitroso aromatic co

1992-10-30

1995-12-05

Chang, Ceila

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514309, C07D21722, A61K 3147

Patent

active

054730740

ABSTRACT:
The subject invention provides for novel compounds for inactivating viruses. These compounds include 6-nitroso-1,2-benzopyrone, 3-nitrosobenzamide, 5-nitroso-1(2H)-isoquinolinone, 7-nitroso-1(2H)-isoquinolinone, 8-nitroso-1(2H)-isoquinolinone. The invention also provides for compositions containing one or more of the compounds, and for methods of treating viral infections, cancer, infectious virus concentration with the subject compounds and compositions.

REFERENCES:
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Ehlhardt, W. J. et al., "Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs." J. Med. Chem. 31:323-329 (1988).
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Noss, M. B. et al., "Preparation, toxicity and mutagenicity of 1-methyl-2-nitrosoimidazole." Biochem. Pharm. 37: 2585-2593 (1988).
Varghese, A. J. et al., "Modification of guanine derivatives by reduced 2-nitroimidazoles." Cancer Research 43: 78-82 (1983).
Buki, K. et al., "Destabilization of Zn(II) coordination in poly(ADP-Ribose) polymerase by 6-nitroso-1,2-benzopyrone coincidental with inactivation of the polymerase but not with the DNA binding function." The Paul Mandel International Meeting of Poly (ADP-Ribosyl)ation Reactions. Abstract 22C May 30, 1991.
Mulcahy, R. T. et al., "Cytotoxicity and glutathione depletioni by I-methyl-2-nitrosoimidazole in human colon cancer cells." Biochem. Pharm. 38: 1667-1671 (1989).
Noss, M. B. et al., "I-Methyl-2-nitrosoimidazole: cytotoxic and glutathione depleting capabilities." Int. J. Radiation Oncology Biol. Phys. 16: 1015-1019 (1989).

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