Adenosine diphosphoribose polymerase binding nitroso aromatic co

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

564163, 564166, A61K 31165, C07C23365

Patent

active

054829755

ABSTRACT:
The subject invention provides for novel compounds for inactivating viruses. These compounds include 6-nitroso-1,2-benzopyrone, 3-nitrosobenzamide, 5-nitroso-1(2H)-isoquinolinone, 7-nitroso-1(2H)isoquinolinone, 8-nitroso-1(2H)isoquinolinone. The invention also provides for compositions containing one or more of the compounds, and for methods of treating viral infections, cancer, infectious virus concentration with the subject compounds and compositions.

REFERENCES:
patent: 3974289 (1976-08-01), Buckle et al.
patent: 4012407 (1977-03-01), Doyle et al.
patent: 4032544 (1977-06-01), Doyle et al.
patent: 4737517 (1988-04-01), DellaValle et al.
patent: 4845121 (1989-07-01), Witiak et al.
Rice, W. et al., "Induction of endonuclease-mediated apoptosis in tumor cells by C-nitroso-substituted ligands of poly (ADP-ribose) polymerase." Proc. Natl. Acad. Sci. 89 7703-7707 (1992).
Buki, K. et al., "Destabilization of Zn.sup.2+ coordination in ADP-ribose transferase (polymerizing) by C-nitroso-1,2-benzopyrone coincidental with inactivation of the polymerase but not the DNA binding function," FEBS 290: 181-185 (1991).
Kirsten, E. et al., "Cellular regulation of ADP-ribosylation of proteins IV. Conversion of poly (ADP-Ribose) polymerase activity to NAD-glycohydrolase during retinoic acid-induced differentiation of HL60 cells." Experimental Cell Research 194:1-8 (1991).
Buki, K. et al., "Inhibitor binding of adenosine disphophoribosyl transferase to the DNA primer site of reverse transcriptase templates." Biochem. Biophys. Res. Com. 180:496-503 (1991).
Cole, G. et al., "Inhibition of HIV-1 IIIb replication in AA-2 and MT-2 cells in culture by two ligands of poly (ADP-ribose) polymerase: 6-amino-1,2-benzopyrone and 5-iodo-6-amino-1,2-benzopyrone." Biochem. Biophys. Res. Com. 180:504-514 (1991).
Henderson, L. et al., "Primary structure of the low molecular weight nucleic acid-binding proteins of murine leukemia viruses" J. Biol. Chem. 256(16) 8400-8403 (1981).
Gorelick, R. et al., "Point mutants of moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a zinc-finger like" protein sequence, Proc. Natl. Acad. Sci 85:8420-8424 (1988).
Gorelick, R. et al., "Noninfectious human immunodeficiency virus Type 1 mutants deficient in genomic RNA." J. Virol. 64:3207-3211 (1990).
Meric, C. et al., "Characterization of moloney murine leukemia virus mutants with single amino acid substitutions in the Cys-His box of the nucleocapsid protein." J. Virol. 63:1558-1568 (1989).
Aldovini, A. et al., "Mutations of RNA and protein sequences involved in human immunodeficiency virus Type I packaging result in production of noninfectious virus." J. Virol 64:1920-1926 (1990).
Lever, A. et al., "Identification of a sequence required for efficient packaging of human immunodeficiency virus Type I RNA into virions." J. Virol 63:4085-4087 (1989).
Gradwohl, G. et al., "The second zinc-finger domain of poly (ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA." Proc. Natl. Acad. Sci. 87 2990-2994 (1990).
South, T. et al., "113 Cd NMR studies of 1:1 Cd adduct with an 18-residue finger peptide from HIV-1 nucleic acid binding protein, p. 7." J. Am. Chem. Soc. 111 395-396 (1989).
South, T. et al., "Zinc fingers and molecular recognition. Structure and nucleic acid binding studies of an HIV zinc fingerlike domain." Biochem. Pharm. 40:123-129 (1990).
Summers, M. et al., "High-resolution structure of an HIV zinc fingerlike domain via a new NMR-based distance geometry approach." Biochemistry 29:329-340 (1990).
Yamagoe, S. et al., "Poly (ADP-ribose) polymerase inhibitors suppress UV-induced human immunodeficiency virus type 1 gene expression at the posttranscriptional level." Molecular and Cellular Biology 11(7) 3522-3527 (1991).
Krasil'Nikov, I. et al., "Inhibitors of ADP-ribosylation as antiviral drugs: Experimental study of the model of HIV infection." VOPR. Virusol (Russia) 36(3) 216-218 (1991).
Furlini, G. et al., "Increased poly (ADP-ribose) polymerase activity in cells infected by human immunodeficiency virus type-1." Microbiologica 14(2) 141-148 (1991).
Ibna-Rasa, K. et al., "O-Nitrosobenzamide. A possible intermediate in the von Richter reaction." J. Org. Chem. 28(11) 3240-3241, 1963.
Seidel, W. et al., "Oxidation of aromatic hydrazides." Chemical Abstracts 82 82 Col. 16505X (1975).
Wubbels, G. et a., "Mechanism of water-catalyzed photo-isomerization of p-nitrobenzaldehye." J. Org. Chem. 47(24) 4664-4670 (1982).
Kovacic, P. et al., "Reduction potentials in relation to physiological activities of benzenoid and heterocyclic nitroso compounds: comparison with the nitro precursors," Bioorganic Chemistry 18: 265-275 (1990).
Ehlhardt, W. J. et al., "Nitrosoimidazoles: highly bactericidal analogues of 5-nitroimidazole drugs." J. Med. Chem. 31: 323-329 (1988).
McClelland, R. A. et al., "Products of the reductions of 2-nitroimidizoles." J. Am. Chem. Soc. 109: 4308-4314 (1987).
Noss, M. B. et al., "Preparation, toxicity and mutagenicity of 1-methyl-2-nitrosoimidazole." Biochem. Pharm. 37: 2585-2593 (1988).
Varghese, A. J. et al., "Modification of guanine derivatives by reduced 2-nitroimidazoles." Cancer Research 43: 78-82 (1983).
Buki, K. et al., "Destabilization of Zn(II) coordination in poly(ADP-Ribose) polymerase by 6-nitroso-1,2-benzopyrone coincidental with inactivation of the polymerase but not with the DNA binding function." The Paul Mandel International Meeting of Poly (ADP-Ribosyl)ation Reactions. Abstract 22C May 30, 1991.
Mulcahy, R. T. et al., "Cytotoxicity and glutathione depletioni by I-methyl-2-nitrosoimidazole in human colon cancer cells." Biochem. Pharm. 38: 1667-1671 (1989).
Noss, M. B. et al., "I-Methyl-2-nitrosoimidazole: cytotoxic and glutathione depleting capabailities." Int. J. Radiation Oncology Biol. Phys. 16: 1015-1019 (1989).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Adenosine diphosphoribose polymerase binding nitroso aromatic co does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adenosine diphosphoribose polymerase binding nitroso aromatic co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenosine diphosphoribose polymerase binding nitroso aromatic co will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1303445

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.