Adenosine derivatives and use thereof

Details Adenosine derivatives and use thereof Adenosine derivatives and use thereof

2005-08-30

2005-08-30

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S045000, C514S256000, C514S351000, C514S359000, C514S381000, C536S027220, C536S025320, C536S022100, C536S025310, C536S028500, C544S277000, C252S299630, C546S296000, C548S311100

Reexamination Certificate

active

06936596

ABSTRACT:
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent effects of lowering ocular tension, promoting blood flow in retina, and protecting optic nerve failure and are highly soluble in water. Owing to these characteristics, the compounds are useful as drugs such as remedies for glaucoma and ocular hypertension.

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Toichi Abiru et al.: “The antihypertensive effect of 2-alkynyladenosines and their selective affinity for adenosine A2 receptors” European Journal of Pharmacology, vol. 196, No. 1, pp. 69-76 1991.
C.E. Crosson: “Adenosine receptor activation modulates intraocular pressure in rabbits” The Journal of Pharmacology and Experimental therapeutics, vol. 273, No. 1, pp. 320-326 1995.

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