Adenosine derivatives

Details Adenosine derivatives Adenosine derivatives

1982-04-14

1984-08-07

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 26, A61K 3170, C07H 1906

Patent

active

044643616

ABSTRACT:
Adenosine derivatives of the general formula: ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which R.sup.5 and R.sup.6 are each hydrogen, alkoxy or arylthio and R.sup.7 is hydrogen or halogen, or a group of the formula: ##STR3## and R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or alkanoyl, and pharmaceutically acceptable salt thereof.
These derivatives and salts thereof are useful as antihypertensives, bradycardiacs, etc. The method of production thereof and pharmaceutical compositions based on those adenosine derivatives or salts are also described.

REFERENCES:
patent: 3590029 (1971-06-01), Koch et al.
patent: 3901876 (1975-08-01), Vorbruggen et al.
patent: 3988317 (1976-10-01), Kampe et al.
Kawazoe et al., Arzneim-Forsch./Drug Res. 30 (II), p. 1083 (1980).
Takeshi Endo et al., "Oxidation of N6, N6-Dialkyl-2', 3', 5'-tri-O-acyl adenosines with ruthenium tetroxide and a novel selective N-monodealkylation sequence," Journal of Organic Chemistry, vol. 44, No. 21 (1979) pp. 3652-3656.
Y. Midorikawa et al., "Conversion of Hypoxanthine Derivatives to Succinyladenine Derivatives by Bacillus subtilis," Chemical Abstracts, vol. 77, No. 25 (1972) p. 285, Abstract No. 163025r.

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