Adenosine deaminase resistant antiviral purine nucleosides and m

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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26034846, 424253, 544254, 544264, 544265, 544277, 560 20, 560106, 560121, 560250, 560252, C07D23942, C07D47330, C07D47334, C07D47338

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active

041385624

ABSTRACT:
The preparation of (.+-.)-9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl) cyclopentyl)]-6-substituted purines: ##STR1## and (.+-.)-3-[.alpha.-(2.alpha., 3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cyclopentyl)]-7-substituted-v-tr iazolo[4,5d]pyrimidines: ##STR2## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR3## wherein R' and R" may be the same or different and are of hydrogen, methyl, ethyl, propyl or phenyl. The preparation of the single intermediate from which either of these series of compounds may be synthesized is also disclosed. The compounds exhibit antiviral and antitumor activity.

REFERENCES:
patent: 3825541 (1974-07-01), Vince
Holy, Chemical Abstracts, vol. 85, Abstract No. 63277w (1976).
Holy, Nucleic Acids Res., Spec. Publ., 1975, 1 (Symp. Chem. Nucleic Acids Components, 3rd, 1975), 573-576.

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