Adenosine deaminase resistant antiviral purine nucleosides and m

Details Adenosine deaminase resistant antiviral purine nucleosides and m Adenosine deaminase resistant antiviral purine nucleosides and m

1978-12-22

1980-09-16

Breitenstein, G. T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560106, 560250, C07C 7946

Patent

active

042231566

ABSTRACT:
The preparation of (+)-9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cyclope ntyl)]-6-substituted purines: ##STR1## and (+)-3-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cyclope ntyl)]7-substituted-v-triazolo[4,5d]pyrimidines: ##STR2## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR3## wherein R' and R" may be the same or different and are of hydrogen, methyl, ethyl, propyl or phenyl. The preparation of the single intermediate from which either of these series of compounds may be synthesized is also disclosed. The compounds exhibit antiviral and antitumor activity.

REFERENCES:
patent: 3646113 (1972-02-01), Rick et al.
patent: 3708586 (1973-01-01), Simon et al.

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