Adenosine deaminase resistant antiviral purine arabinonucleoside

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544264, 544265, 424253, C07D47332, A61K 3152

Patent

active

043831141

ABSTRACT:
The preparation of 9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl) cyclopentyl)]-6-substituted purines: ##STR1## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR2## wherein R' and R" may be the same or different and are hydrogen, methyl, ethyl, propyl or phenyl. The compounds exhibit anti-viral and antitumor activity and are resistant to adenosine deaminase. Acid salts and esters of the purine nucleosides have also been prepared.

REFERENCES:
patent: 4138562 (1979-02-01), Vince
patent: 4268672 (1981-05-01), Vince
CA, vol. 75, 86 554s (1971).
Jac S, vol. 91, 3075-3083 (1969).

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