Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1980-01-14
1982-02-16
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424253, 424 10, A61K 3170, A61K 3152
Patent
active
043159206
ABSTRACT:
Pharmaceutical preparations containing compounds of the formula ##STR1## where R is alkyl of 1 to 11 carbons. The preparations are useful in inhibiting adenosine deaminase in mammals thereby providing a method for prolonging the effectiveness of pharamaceutical agents which are biologically degraded by adenosine deaminase and thus converted into other compounds.
REFERENCES:
Koshiura et al., Cancer Research, vol. 28, 1968, pp. 1014-1020.
Schaeffer et al., J. Med. Chem., vol. 17, No. 1, pp. 6-8 (1973).
DeMiranda Paulo M. S.
Elion Gertrude B.
Hitchings George H.
Schaeffer Howard J.
Brown Donald
Burroughs Wellcome Co.
Goldberg Jerome D.
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