Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-10-27
1998-01-06
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 2162, 536 2763, 536 277, A61K 3170, C07H 19167
Patent
active
057054916
ABSTRACT:
The present invention relates to adenosine deaminase inhibitors containing at least one O-alkylated moiety and the pharmaceutically acceptable salts thereof.
The pharmaceutical compositions of the present invention include adenosine deaminase inhibitors containing at least one of the compounds represented by Formula (I): ##STR1## wherein each of R.sub.1, R.sub.2, and R.sub.3 are the same or different and is hydrogen or alkyl;
REFERENCES:
patent: 4843066 (1989-06-01), Yamada et al.
patent: 4985409 (1991-01-01), Yamada et a.
The 1991 Sigma Chemical Company Catalog, St. Louis, Missouri, pp. 41 and 660.
Chemical Abstract vol. 66, No. 3, Abstr. No. 8441c, Rockwell et al. Mol. Pharmacol. 2(6):574-584, 1966.
J. G. Niedzwicki, et al., "Structure-Activity Relationship of Ligands of Human Plasma Adenosine Deaminase.sub.2 ", Biochemical Pharmacology, vol. 41, No. 11, 1991, pp. 1615-1624.
Phillis, et al., "Brian Adenosine and Transmitter Amino Acid Release from the Ischemic Rat Cerebral Cortex: Effects of the Adenosine Deaminase Inhibitor Deoxycoformycin", Journal of Neurochemistry, vol. 56, No. 2, pp. 644-650 (1991).
Cristalli, et al., "Adenosine Deaminase Inhibitors: Synthesis and Structure-Activity Relationship of 2-Hydroxy-3-nonyl Derivatives of Azoles", J. Med. Chem., vol. 37, pp. 201-205 (1994).
Zhu, et al., "Protective Effects of an adenosine deaminase inhibitor on ischemia-reperfusion injury in isolated perfused rat heart", Am. J. Physiol., vol. 259, H835-H838 (1990).
Kato, et al., "Effects of Antiasthma Drugs on Superoxide Anion Generation from Human Polymorphonuclear Leukocytes or Hypoxanthine-Xanthine Oxidase System", Int. Arch. Allergy Appl. Immunol.,vol. 96, pp. 128-133 (1991).
Rockwell, et al., "Studies on Adenosine Deaminase I. Purification and Properties of Ox Heart Adenosine Deaminase," Mol. Pharmacol. 2, 574-584 (1966).
Kunz Gary L.
Nippon Zoki Pharmaceutical Co. Ltd.
LandOfFree
Adenosine deaminase inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adenosine deaminase inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenosine deaminase inhibitor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2329278