Adenosine cyclic 3',5'-phosphate triesters and the acid addition

Details Adenosine cyclic 3',5'-phosphate triesters and the acid addition Adenosine cyclic 3',5'-phosphate triesters and the acid addition

1981-11-02

1983-08-30

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1920, C07H 1900

Patent

active

044018088

ABSTRACT:
Triesters of adenosine cyclic 3',5'-phosphoric acid having cardiotonic, diuretic and anti-tumor activities represented by the following formula ##STR1## wherein R represents a linear or branched alkyl group having 5 to 15 carbon atoms, and the acid addition salts thereof; and a process for production thereof.

REFERENCES:
Engels, J. and Schlaeger, E., J. Med. Chem., vol.207, pp. 907-911, 1977.
Gohil, R., et al., Nuclic Acid Research, vol.1, pp. 1691-1701, 1974.
Korth, M. and Engels, J., Archieves of Pharmacology, vol. 310, pp. 103-111, 1979.
Nagyvary, J., et al., Biochem. Biophys. Res. Comm., vol. 55, pp. 1072-1077, 1973.
Colton, F., et al., Proc. Nat. Acad. Sci. vol. 72, pp. 1335-1339, 1975.
Chemistry of Organic compounds, Ed. by Carl R. Noller, pp. 321-322, 1965, W. B. Saunders Company, Philadelphia.

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