Adenosine compounds useful in the prevention and treatment of va

Details Adenosine compounds useful in the prevention and treatment of va Adenosine compounds useful in the prevention and treatment of va

1989-10-03

1992-04-07

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 536 26, 536 24, A61K 3170, C07H 19167, C07H 19173

Patent

active

051028735

ABSTRACT:
Substituted 1-(benzyloxy)adenosines and the use of substituted 1-(benzyloxy)adenosines and adenosine-N.sup.1 -oxides in the prevention and treatment of vaccinia virus infections are disclosed.

REFERENCES:
Krauth et al., "Synthesis and Antiviral Evaluation of Adenosine-N.sup.1 -oxide and 1-(Benzyloxy) Adenosines," in Nucleosides, Nucleotides, and Their Biological Applications, Oct. 4, 1988, Orange Beach, Ala., U.S.A., see p. 31, Abstract 38.
Fujii et al., "3-Methyladenine Nucleosides: Their Synthesis, Ring Opening, and Glycosidic Bond Cleavage," in Nucleic Acids Research Symposium Series No. 8, IRL Press Limited, London, England, 1980, pp. s17-s19.
Kaneko et al., Chem. Abstr., 106: 196,740r (1987).
Fujii et al., Chem. Abstr., 102: 220,260z (1985).
Shannon et al., J. Med. Chem., 17, 361-363 (1974).
Krauth et al., "Synthesis and Antiviral Evaluation of Adenosine-N.sup.1 -oxide . . . ", Nucleosides-Nucleotides, 8, 915-917 (1989).

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