Adenosine as a positive inotrop in the compromised heart

Details Adenosine as a positive inotrop in the compromised heart Adenosine as a positive inotrop in the compromised heart

1995-03-13

1997-05-13

Bleutge, John C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, 514263, 536 276, 536 2613, C07H 1916, C07H 19167

Patent

active

056292988

ABSTRACT:
Disclosed are methods of increasing the contractile performance of a compromised myocardium in a mammal. The methods include administering a therapeutically affective amount of an adenosine A.sub.2 receptor agonist. Also disclosed are methods that include administering in conjunction with an adenosine A.sub.2 receptor agonist a second compound which potentiates the beneficial effect of the adenosine A.sub.2 receptor agonist, e.g., an adenosine transport inhibitor, an inhibitor of adenosine metabolism or an adenosine A.sub.1 receptor antagonist.

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