Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-09
2008-12-30
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S251000
Reexamination Certificate
active
07470698
ABSTRACT:
The compounds of the following formula:wherein R, R2, R3and A have the meanings given in the specification, are endowed with selective A3adenosine receptor antagonist activity. These compounds can be used in a pharmaceutical composition to treat disorders caused by excessive activation of the A3receptor, or can be used in a diagnostic application to determine the relative binding of other compounds to the A3receptor. The compounds can be labeled, for example with fluorescent or radiolabels, and the labels used in vivo or in vitro to determine the presence of tumor cells which possess a high concentration of adenosine A3receptors.
REFERENCES:
patent: 6407236 (2002-06-01), Baraldi et al.
patent: 6448253 (2002-09-01), Baraldi
patent: 2005/0119289 (2005-06-01), Borea et al.
Muller, C., Medicinal Chemistry of Adenosine A3 Receptor Ligands, Current Topics in Medicinal Chemistry, 3, 445-462 (2003).
Baraldi Pier Giovanni
Borea Pier Andrea
King Pharmaceuticals Research and Development, Inc.
Kukkola Paivi
Wilson James O.
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