Adenosine A2a receptor antagonists

Details Adenosine A2a receptor antagonists Adenosine A2a receptor antagonists

2006-06-27

2006-06-27

Pryor, Alton (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C544S238000, C544S251000, C544S230000

Reexamination Certificate

active

07067655

ABSTRACT:
Compounds having the structural formula Ior a pharmaceutically acceptable salt thereof, whereinR is optionally substituted phenyl, cycloalkenyl, or heteroaryl;X is alkylene or —C(O)CH2—;Y is —N(R2)CH2CH2N(R3)—, —OCH2CH2N(R2)—, —O—, —S—, —CH2S—, —(CH2)2—NH—, or optionally substitutedm and n are 2–3, and Q is nitrogen or optionally substituted carbon; andZ is optionally substituted phenyl, phenylalkyl or heteroaryl, diphenylmethyl, R6—C(O)—, R6—SO2—, R6—OC(O)—, R7—N(R8)—C(O)—, R7—N(R8)—C(S)—,phenyl-CH(OH)—, or phenyl-C(═NOR2)—; or when Q is CH, phenylamino or pyridylamino; orZ and Y together are substituted piperidinyl or substituted phenyl; andR2, R3, R6, R7, and R8are as defined in the specification are disclosed, their use in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them; also disclosed are a processes for preparing intermediates useful for preparing compounds of formula I.

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