Adenosine A2a receptor antagonists

Details Adenosine A2a receptor antagonists Adenosine A2a receptor antagonists

2006-05-09

2006-05-09

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S263000, C544S118000, C544S244000, C514S262100, C514S081000

Reexamination Certificate

active

07041666

ABSTRACT:
Disclosed are compounds having the structural formulaor pharmaceutically acceptable salts or solvates thereof, whereinR is optionally substituted heteroaryl, optionally substituted phenyl, cycloalkenyl, —C(═CH2)CH3, —C≡C—CH3,—CH═C(CH3)2,or —CH═CH—CH3;R2is —W—X, —NR19(CH2)m—W—X, and —NR19CH(CH3)—W—X, orR2is alkyl, alkenyl and —NR18R19, each optionally substituted —W—X;R3is H, halo, alkyl, trifluoromethyl, alkoxy, alkoxyalkyl, hydroxyalkyl, alkylamino, alkylaminoalkyl, dialkylamino, dialkylaminoalkyl, aminoalkyl, aryl, heteroaryl, or CN;R18is a bond, —CH(OH)—, —CH(CH3)—, —C(CH3)n—, —(CH2)n—or —O(CH2)n—;W is aryl or heteroaryl, each optionally substituted;X is H, NH2, or substituted amino, or X is —R18—Y-Z;and n, R19, Y and Z are as defined in the specification;pharmaceutical compositions thereof, and methods of treating stroke or central nervous system diseases by administering the compound of the present invention to a patient in need of such treatment.

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