Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-03-05
1999-09-14
Crouch, Deborah
Chemistry: molecular biology and microbiology
Vector, per se
514 44, 424 931, 435325, C12N 1563, C12N 1585, A61K 4800
Patent
active
059522216
ABSTRACT:
The use of recombinant adeno-associated virus (AAV) virions for the treatment of solid tumors is disclosed. The invention provides for the use of recombinant AAV virions to deliver an AAV vector containing a drug-susceptibility gene and a second gene capable of providing an ancillary effect to solid tumor cells. The second gene can be used to enhance the immunogenicity of the transduced tumor cell. Alternatively, the second gene can be used to provide a tumorstatic effect. The invention also provides for the use of recombinant AAV virions to deliver an interferon gene, or a tumor suppressor gene to provide a therapeutic effect in a transduced tumor cell.
REFERENCES:
patent: 5252479 (1993-10-01), Srivastava
patent: 5601818 (1997-02-01), Freeman et al.
Vieweg et al. (1995) Cancer Investigation, vol. 13(2), 193-201, 1995.
Gura (1997) Science, vol. 278, 1041-1042, Nov. 1997.
Orkin et al. (1995) "Report and Recommendations of the panel to assess the NIH investment in research on gene therapy", 1995.
Ross et al. (1996) Human Gene Therapy, vol. 7, 1781-1790, Sep. 1996.
Zhang et al. (1996) Cancer Gene Therapy, vol. 3 (1), 31-38, Jan. 1996.
Su et al. (1996) Human Gene Therapy, vol. 7, 463-470, Mar. 1, 1996.
Chen et al. (1995) Proc. Natl. Acad. Sci. USA, vol. 92, 2577-2581, 1995.
Zhang et al. (1994) Cancer Gene Therapy, vol. 1 (1), 5-13, 1994.
Tani, Kenzaburo. Gene Therapy for Cancer, 29(10) 1117-22, 1993.
Hooghe-Peters E et al., Gene Therapy, 1 Suppl 1 S80, 1994.
Finegold et al., PNAS, 92(7) 2577-81, May 2, 1995.
Taylor et al., Cancer Gene Therapy, 3 (1) 31-8, Jan. 1996.
Su et al., Human Gene Therapy, 7:463-470, Mar. 1996.
Lauret et al., "Development of Methods for Somatic Cell Gene Therapy Directed Against Viral Diseases, Using Retroviral Vectors Carrying the Murine or Human Interferon-.beta. Coding Sequence: Establishment of the Antiviral State in Human Cells," Human Gene Therapy 4:567-577 (1993).
Yagi et al., "Interferon-.beta. Endogenously Produced by Intratumoral Injection of Cationic Liposome-Encapsulated Gene: Cytocidal Effect on Glioma Transplanted Into Nude Mouse Brain," Biochem. And Molecular Biol. Intl. 32(1):167-171 (1994).
Zhang et al., "Gene Therapy With an ADENO-Associated Virus Carrying an Interferon Gene Results in Tumor Growth Suppression and Regression," Cancer Gene Therapy 3(1):31-38 (1996).
Database WPI, "Recombinant DNA and Transformed Cells Having Human Interferon Gene Used for Production of Human Interferon Having Antiviral and Antitumour Activities," Derwent Publ. Ltd. 1 page (1988).
Zhang et al. (1995) J. Cell. Biochem., Suppl. 21A, 422, 1995.
Anderson et al. (1995) Exp. Hematol., vol. 23 (8), 994(a), 1995.
Anderson et al. (1995) Blood, vol. 86 (10), 939, 1995.
Badie et al., "Stereotactic Delivery of a Recombinant Adenovirus into a C6 Glioma Cell Line in a Rat Brain Tumor Model," Neurosurgery 35(5):910-916 (1994).
Bonnekoh et al., "Inhibition of Melanoma Growth by Adenoviral-Mediated HSV Thymidine Kinase Gene Transfer," J. of Investigative Dermatology 104(3):313-317.
Chambers et al., "Comparison of Genetically Engineered Herpes Simplex Viruses for the Treatment of Brain Tumors in a Scid Mouse Model of Human Malignant Glioma," Proc. Natl. Acad. Sci. USA 92:1411-1415 (1995).
Chen et al., "Gene Therapy for Brain Tumors: Regression of Experimental Gliomas by Adenovirus-Mediated Gene Transfer In Vivo," Proc. Natl. Acad. Sci. USA 91:3054-3057 (1994).
Culver et al., "In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors," Science 256:1550-1552 (1992).
DiMaio et al., "Directed Enzyme Pro-Drug Gene Therapy for Pancreatic Cancer In Vivo," Surgery 116:(2):205-213 (1994).
Dong et al., "In Vivo Replication-Deficient Adenovirus Vector-Mediated Transduction of the Cytosine Deaminase Gene Sensitizes Glioma Cells to 5-Fluorocytosine," Human Gene Therapy 7:713-720 (1996).
Goodman et al., "Adenoviral-Mediated Thymidine Kinase Gene Transfer into the Primate Brain Followed by Systemic Ganciclovir: Pathologic, Radiologic, and Molecular Studies," Human Gene Therapy 7:1241-1250 (1996).
Huber et al., "Retroviral-Mediated Gene Therapy for the Treatment of Hepatocellular Carcinoma: An Innovative Approach for Cancer Therapy," Proc. Natl. Acad. Sci. USA 88:8039-8043 (1991).
Ishii et al., "Mechanism of `Bystander Effect` Killing in the Herpes Simplex Thymidine Kinase Gene-Modified Tumor System," J. Cell Biochem. Suppl. 18A, p. 226, Abstract DZ116 (1994).
Macri et al., "Delayed Morbidity and Mortality of Albumin/SV40 T-Antigen Transgenic Mice after Insertion of an .alpha.-Fetoprotein/Herpes Virus Thymidine Kinase Transgene and Treatment with Ganciclovir," Human Gene Therapy 5:175-182 (1994).
Manome et al., "Viral Vector Transduction of the Human Deoxycytidine Kinase cDNA Sensitizes Glioma Cells to the Cytotoxic Effects of Cytosine Arabinoside In Vitro and In Vivo," Nature Medicine 2(5):567-573 (1996).
Manome et al., "Gene Therapy for Malignant Gliomas Using Replication Incompetent Retroviral and Adenoviral Vectors Encoding the Cytochrome P450 2B1 Gene Together with Cyclophosphamide," Gene Therapy 3:513-520 (1996).
Markert et al., "Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir," Neurosurgery 32(4):597-603 (1993).
Martuza et al., "Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant," Science 252:854-856 (1991).
Okada et al., "Gene Therapy Against an Experimental Glioma Using Adeno-Associated Virus Vectors," Gene Therapy 3:957-964 (1996).
Perez-Cruet et al., "Adenovirus-Mediated Gene Therapy of Experimental Gliomas," J. Neuroscience Research 39:506-511 (1994).
Plautz et al., "Selective Elimination of Recombinant Genes In Vivo With a Suicide Retroviral Vector," New Biologist 3(7):709-715 (1991).
Qian et al., "Induction of Sensitivity to Ganciclovir in Human Hepatocellular Carcinoma Cells by Adenovirus-Mediated Gene Transfer of Herpes Simplex Virus Thymidine Kinase," Hepatology 22(1):118-123 (1995).
Ram et al., "The Effect of Thymidine Kinase Transduction and Ganciclovir Therapy on Tumor Vasculature and Growth of 9L Gliomas in Rats," J. Neurosurg. 81:256-260 (1994).
Shinoura et al., "Protein and Messenger RNA Expression of Connexin43 in Astrocytomas: Implications in Brain Tumor Gene Therapy," J .Neurosurg. 84:839-846 (1996).
Takamiya et al., "Gene Therapy of Malignant Brain Tumors: A Rat Glioma Line Bearing the Herpes Simplex Virus Type 1-Thymidine Kinase Gene and Wild Type Retrovirus Kills Other Tumor Cells," J. Neuroscience Research 33:493-503 (1992).
Colosi Peter C.
Kurtzman Gary J.
Mizuno Masaaki
Okada Hideho
Yoshida Jun
Avigen, Inc.
Beckerleg A.M. S.
Crouch Deborah
LandOfFree
Adeno-associated virus vectors comprising a first and second nuc does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adeno-associated virus vectors comprising a first and second nuc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adeno-associated virus vectors comprising a first and second nuc will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1509389