Adeno-associated virus vector for boosting immunogenicity of...

Details Adeno-associated virus vector for boosting immunogenicity of... Adeno-associated virus vector for boosting immunogenicity of...

2006-02-21

2006-02-21

Salimi, Ali R. (Department: 1648)

Chemistry: molecular biology and microbiology

Vector, per se

C435S006120, C435S325000, C435S235100

Reexamination Certificate

active

07001765

ABSTRACT:
The present invention provides an Adeno-Associated Virus (AAV) vector having a foreign DNA coding for a protein that boosts immunogenicity of cells. The invention also provides a vaccine containing such a vector and the use of both.

REFERENCES:
patent: WO 94/21808 (1994-09-01), None
patent: WO 94/24267 (1994-10-01), None
patent: WO 95/14101 (1995-05-01), None
patent: WO 95/14771 (1995-06-01), None
patent: WO 95/27494 (1995-10-01), None
Chiorini et al, Human Gene Therapy, Dec. 1995, vol. 6, pp. 1531-1541.
Hallek, M. et al., “Human Lymphoid Tumor Cells Transduced With Recombinant Adeno-Associated Virus (Aav) Vectors Containing B7-1 And B7-2 Genes Provide Potent Costimulatory Signal For T-Cell Proliferation”,Blood 86(10): (Supp1)1995.
Shaughnessy et al., “Parvoviral Vectors For The Gene Therapy Of Cancer”,Seminars in Oncology, 23(1):159-171 (1996).
Wendtner, C.M. et al., “Human Lymphoma Cells Transduced With Recombinant Adeno-Associated Virus (AAV) Vectors Containing B7-1 and B7-2 Genes Provide Potent Costimulatory Signal For T-cell Proliferation”,Oncology 18: (Supp2) 32 (1995).
Wendtner, C.M. et al., Efficient, Stable And Functional Expression Of Costimulatory Molecules Of B7-1 (CD80) And B7-2 (CD86) In Human Lymphoma Cells By An Improved Adeno-Associated Virus (AAV) Vector,Journal of Molecular Medicine 73(4): B13-B14 (1995).
Zhang et al., “Gene Therapy With An Adeno-Associated Virus Carrying An Interferon Gene Results In Tumor Growth Suppression And Regression”,Cancer Gene Therapy 3(1):31-38 (1996).

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