Adeno-associated virus materials and methods

Details Adeno-associated virus materials and methods Adeno-associated virus materials and methods

1996-09-10

1999-01-12

Guzo, David

Chemistry: molecular biology and microbiology

Vector, per se

536 231, 536 2372, C12N 1586, C07H 2104

Patent

active

058587756

ABSTRACT:
The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders.

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