Adeno-associated virus as eukaryotic expression vector

Details Adeno-associated virus as eukaryotic expression vector Adeno-associated virus as eukaryotic expression vector

1985-03-15

1989-01-10

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Vector, per se

435 68, 435 70, 435 91, 4351723, 435317, 435235, 935 32, 935 34, 935 57, 536 27, C12N 700, C12N 1500, C12P 1934, C12P 2100

Patent

active

047973684

ABSTRACT:
The present invention relates to a vector comprising part of AAV DNA contained in a plasmid and capable of being packaged into AAV particles and functioning as a vector for stable integration and expression of a gene in eukaryotic cells when under control of an AAV transcription promoter. A method of preparing such plasmids which are packagable and rescuable is also described.

REFERENCES:
patent: 4419446 (1983-12-01), Howley et al.
Tratschin, J. et al. (Sep. 1984) J. Virol 51:611-619.
Tratschin, J. et al. (Oct. 1984) Molec. Cell. Biol. 4:2072-2081.
Hermonat, P. and N. Muzyczka (Oct. 1984) PNAS 81:6466-6470.
Laughlin et al., Gene, 23 (1983) 65-73.

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