Adenine derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424200, 544244, 544277, A61K 3152

Patent

active

043235735

ABSTRACT:
Novel 2-amino substituted adenine compounds and their use as antiviral compounds are disclosed. In particular the compound 2-amino-9-(2-hydroxyethoxymethyl) adenine is particularly advantageous as an antiviral in that it has high oral absorption and that upon metabolism in mammals, it has the property of being converted to 9-(2-hydroxyethoxymethyl) guanine which is also a highly active antiviral.

REFERENCES:
patent: 4146715 (1979-03-01), Schaeffer
McDonald et al., Phytochemistry, 1971, 10(7), 1429-1439.
Shealy et al., J. Org. Chem., 1961, 26(11), 4433-4440.

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