Adenine derivatives

Details Adenine derivatives Adenine derivatives

1976-07-14

1978-05-23

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 27, 544276, C07H 1916

Patent

active

040912035

ABSTRACT:
A method is disclosed for preparing functionalized adenine derivatives, said method comprising the step of reacting a compound which contains an adenine nucleus which has been halogen substituted in the 8-position, with a compound having the general formula M.sup.+- S--(CH.sub.2).sub.n --COO.sup.- M.sup.+ wherein M.sup.+ is the ion of an alkali metal and n is an integer, the reaction being carried out in a polar aprotic solvent. Procedures for preparing macromolecularized adenine compounds are also indicated by reacting a functionalized adenine derivative with a polymer which has at least one primary or secondary aminic group in its structure.

REFERENCES:
patent: 3712885 (1973-01-01), Weimann et al.
Hildesheim et al., Biochimie, vol. 55 (1973) pp. 541-546.

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