Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-05-03
2005-05-03
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S263220, C514S263230, C514S263400, C544S277000
Reexamination Certificate
active
06887880
ABSTRACT:
The present invention relates to derivatives and analogues of adenine of the formula:wherein L, A, Y and Z are those defined herein. Compounds of the present invention are useful in inhibiting adenylyl cyclase activity. The present invention also relates to a method of preventing and inhibiting a patient's fibroproliferative vasculopathy following vascular injury or a vascular surgical operation which includes administering to the patient, an effective amount of a compound according to the invention subsequent to a vascular injury, or subsequent to a vascular surgical operation, for one to two weeks after the injury or surgical operation, effective to treat or prevent a patient's fibroproliferative vasculopathy such as chronic allograft rejection or vascular restenosis following vascular trauma. The present invention also relates to a method for measuring the inhibition of adenylyl cyclase activity and a method for treating congestive heart failure.
REFERENCES:
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patent: WO 9915509 (1999-04-01), None
Maurinsh, Y.; et al J. Org. Chem. 1997; 62(9); 2861-2871.*
Wolfrom, J. Organic Chem. 1099-1101 (1965).*
Okumura, J. Medical Chem, 17(8), 846 (1974) pp. 846-855.*
Saito, Tet. Letters (1970) 4863-4866.*
Holy, Coll. Czech. Chem. Comm. 50, 262 (1885).
Kane-Maguire Kim
Levy Daniel
Marlowe Charles
Scarborough Robert M.
Berch Mark L.
Millennium Pharmaceuticals Inc.
Townsend and Townsend / and Crew LLP
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