Adenine and guanine derivatives for the treatment of hepatitis v

Details Adenine and guanine derivatives for the treatment of hepatitis v Adenine and guanine derivatives for the treatment of hepatitis v

1991-07-17

1994-12-20

Weimar, Elizabeth C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 514 46, 514 49, 536 221, A01N 4304, A61K 3170, C07H 1900

Patent

active

053746252

ABSTRACT:
A novel nucleic acid derivative represented by the following general formula (I) and physiologically acceptable salt thereof which are expected to have an antiviral activity: ##STR1## wherein B represents a nucleic acid base derivative; A.sup.1 and A.sup.2 represent, independently of each other, OR.sup.1 or OCOR.sup.1 ; R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; l represents a number of 0 or 1; and m and n each represents an integer of 0-2; provided that when l and m are 0, n is 0 or 2.

REFERENCES:
patent: 4383114 (1983-05-01), Vince
patent: 4988703 (1991-01-01), Norbeck et al.
The Journal of Antibiotics, vol. XLII, No. 4, 1989 pp. 644-646.
Antimicrobial Agents and Chemotherapy, vol. 32, No. 7, 1988, pp. 1053-1056.
Medical Research Review vol. 6, No. 1, pp. 1-40 (1986).
Journal of the Chemical Society, Chemical Communications, No. 24: 1989, pp. 1919-1921; Ichikawa et al., "Enantio- and Diastereo-Selective Synthesis of Carbocyclic . . . ".
The Journal of Antibiotics, vol. XLII, No. 12, Dec. 1989, pp. 1854-1859; Nishiyama et al.: "Anti-Herpes Virus Activity of Carbocyclic Oxetanocin . . . ".
Chemical and Pharmaceutical Bulletin, vol. 38, No. 1, Jan. 1990, pp. 288-290. Katagiri et al.: "Highly Stereoselective Synthesis of Carbocyclic Analogues . . . ".

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