Adduct salts of novel substituted benzylamines and a process for

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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564304, C07C20900, C07B 5700

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active

058565795

ABSTRACT:
A process for optical resolution of a racemic substituted benzylamine is provided that involves reacting the racemic substituted benzylamine in a solvent with an optically active N-acyl-phenylalanine, -aspartic acid, or -glutamic acid, and separating the diastereomers formed by making use of the difference in the mutual solubilities of the two diastereomer salts which are generated therein.

REFERENCES:
patent: 3028430 (1962-04-01), Gillingham
patent: 5629450 (1997-05-01), Hijiya et al.
Database WPI, Derwent Publications, AN-94-163883, JP-06-107604, Apr. 19, 1994.
Journal of the American Chemical Society, vol. 73, No. 12, pp. 5782-5783, Dec. 24, 1951, H. D. DeWitt, et al., "N-Acylamino Acids, A New Class of Resolving Agents".

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