Additive sterol solution and method for preserving normal red ce

Surgery – Blood drawn and replaced or treated and returned to body

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604403, 604262, 424101, 435 2, A61M 103, A61K 3514, A01N 100

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active

044327501

ABSTRACT:
An additive solution is used to preserve normal red blood cell morphology during storage. The solution comprises a concentration of a nontoxic, physiologically compatible sterol, such as cholesterol, epi-cholesterol, lanosterol, stigmasterol, ergosterol, desmosterol, fucosterol, cholestanol, epi-cholestanol, coprosterol, epi-coprosterol, lathosterol, or campesterol. The sterol is present in a concentration of between approximately 1.0 and 3.0 milligrams per milliliter of whole blood.

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patent: 4326025 (1982-04-01), Buckles et al.
Ponder, Hemolysis and Related Phenomena, Grune and Stratton, New York, 1948, pp. 263-287.
Cooper et al., "Modification of Red Cell Membrane Structure by Cholesterol-Rich Lipid Dispersions", The Journal of Clinical Investigation, vol. 55, Jan. 1975, pp. 115-126.
DeVenuto et al., "Distribution of Progesterone and Its Affect on Human Blood During Storage", Transfusion, Mar.-Apr. 1976, pp. 107-112.
Little and Rumsby, Scand. J. Hematol. (1980) 25, pp. 134-140.
Little and Rumsby, "Lysis of Erythrocytes from Stored Blood by Phosopholipase C", Bio Chemical Journal, (1980), vol. 188, pp. 39-46.
Laczko et al., "Discocyte, Echinocyte Reversibility and Blood Stored in CPD Over a Period of 56 Days", Transfusion, Jul.-Aug. 1979, pp. 379-388.
Fischer-Chem. Abst. vol. 59 (1963) p. 3170G.

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