Additive solution and method for preserving normal red cell morp

Details Additive solution and method for preserving normal red cell morp Additive solution and method for preserving normal red cell morp

1981-12-02

1983-05-31

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435 2, 206438, A61K 3514

Patent

active

043860699

ABSTRACT:
An additive solution, which can be dispersed in whole blood to enhance preservation of normal red cell morphology during storage, comprises a fatty ester which includes at least two ester linkages comprising fatty hydrocarbon groups of about four to twelve carbon atoms each. The solution can be introduced into the whole blood either at the outset of the storage period or any time during the period in an amount to provide, after its introduction, a concentration of the fatty ester of between 150 and 3,000 micrograms per milliliter of whole blood. When introduced at the outset of storage, morphological changes in the red cells are significantly retarded during the storage period. When introduced at later stages of storage, the solution serves to rejuvenate a significant percentage of red cells which have undergone morphological changes prior to the introduction of the solution.

REFERENCES:
patent: 4222379 (1980-09-01), Smith
patent: 4286597 (1981-09-01), Gajewski et al.
patent: 4300559 (1981-11-01), Gajewski et al.
patent: 4301800 (1981-11-01), Collins
patent: 4326025 (1982-04-01), Buckles et al.
Little and Rumsby, Scand. J. Hematol. (1980), 25, pp. 134-140, copyright 1980.
Little and Rumsby, "Lysis of Erythrocytes from Stored Blood by Phospholipase C", Bio Chemical Journal, (1980), vol. 188, pp. 39-46.
Laczko et al., "Discocyte, Echinocyte Reversibility and Blood Stored in CPD Over a Period of 56 Days", Transfusion, Jul.-Aug. 1979, pp. 379-388.

Affiliated with

Also associated with

Rating

Additive solution and method for preserving normal red cell morp does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Additive solution and method for preserving normal red cell morp, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Additive solution and method for preserving normal red cell morp will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2245719