Added array of molecular chains for interfering with electrical

Details Added array of molecular chains for interfering with electrical Added array of molecular chains for interfering with electrical

1987-05-01

1992-05-19

Johnston, Jill A.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Calorimeter

2041531, 204403, 422 8202, 436525, G01N 2702, G01N 33345

Patent

active

051146746

ABSTRACT:
An array of molecular chains is added to a dielectric material between two electrodes of a capacitive affinity sensor. Such an array of molecular chains greatly changes dielectric properties between the two electrodes to greatly enhance sensitivity of the sensor. In a sensor using direct binding, a viral fragment is bound to the sensor's surface. A molecular chain, comprising an anti-viral antibody, an anti-human antibody, and a protein molecule, binds to the viral fragment. In a sensor using competitive binding a hapten is bound to the sensor's surface. A molecular chain, comprising an antibody with attached aliphatic hydrocarbons, binds to the hapten. A free analyte competes with the hapten to bind with the antibody.

REFERENCES:
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patent: 4092116 (1978-05-01), Giaever
patent: 4238757 (1980-12-01), Schenck
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patent: 4562157 (1985-12-01), Lowe et al.
patent: 4571543 (1986-02-01), Raymond et al.
patent: 4637861 (1987-01-01), Krull et al.
patent: 4713347 (1987-12-01), Mitchell et al.
"Adsorption Of Blood Proteins On Metals Using Capacitance Techniques", by Stoner et al., The Journal of Physical Chemistry, vol. 74, No. 5, Mar. 5, 1970.

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