Adaptation sites of porcine reproductive and respiratory...

Details Adaptation sites of porcine reproductive and respiratory... Adaptation sites of porcine reproductive and respiratory...

2007-12-25

2007-12-25

Campell, Bruce R. (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S235100, C435S373000

Reexamination Certificate

active

10407822

ABSTRACT:
A method for determining the capability of an arterivirus to replicate in a permissive cell is disclosed. The method includes determining an amino acid at a position that corresponds to an amino acid of a protein of a porcine reproductive and respiratory syndrome virus. The invention also discloses a method for determining the capability of an arterivirus to replicate in a green monkey cell line. The invention further discloses a method for producing arterivirus in a green monkey cell line wherein the virulence of the arterivirus is maintained and the virus yield is increased. Methods for determining the attenuation of an arterivirus and for attenuating the virulence of the arterivirus by changing amino acids are further disclosed.

REFERENCES:
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