Adamantylglycine-based inhibitors of dipeptidyl peptidase IV...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S210010, C514S227500, C514S231200, C514S299000, C514S319000, C514S367000, C514S374000, C544S059000, C544S106000, C546S112000, C546S195000, C548S200000, C548S215000, C548S452000, C548S528000, C548S953000

Reexamination Certificate

active

06995183

ABSTRACT:
Compounds are provided having the formula (I)wherein:n is 0, 1 or 2;m is 0, 1 or 2;the sum of n+m less then or equal to 2;the dashed bonds forming a cyclopropyl ring can only be present when Y is CH;X is H or CN;Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; andA is adamantyl.Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.

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