Adamantyl Thiazole Thioureas

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S196000

Reexamination Certificate

active

06960606

ABSTRACT:
Novel aromatic and heterocyclic thiazolyl thiourea compounds, pharameutical compositions including such, and methods for their use are disclosed. The compounds are effective agents for the treatment of HIV infection, including non-nucleoside inhibitor-resistant, and multi-drug resistant strains of HIV.

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patent: WO 00/21565 (2000-04-01), None
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Bell, et al.,J. Med. Chem., 1995, 38(25), 4929-36 Phenethylthiazolethiourea (PETT) Compounds a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. synthesis and Basic Structure-Activity Relationship Studies of PETT Analogs.
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Cantrell et al.,J. Med. Chem., 1995,39(21), 4261-4274 Phenethylthiazolylthiourea (PETT) Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 2. Synthesis and Further Structure-Activity Relationship Studies of PETT Analogs.
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